Sunday, September 06, 2009

Corey Wrenn's critique of Vegan Outreach literature

Roanoke Vegan Examiner

A critique of Vegan Outreach literature


September
6, 9:37 PMRoanoke Vegan ExaminerCorey Wrenn



Downed calves
                   Downed calves:  direct result of the dairy industry.
 






Popular utilitarian welfarist group, Vegan Outreach, maintains that in order to help non-human animals now, we must adopt a strategy which aims to reduce suffering, regardless of means.  However, there are critical inconsistencies, misconceptions, and outright misuses of terminology which undermine any real benefit to non-human animals.  Despite their self-designation as a “[…] nonprofit organization dedicated to reducing animal suffering by promoting a vegan lifestyle,” Vegan Outreach in fact hinders veganism with notions of extremism and promotion of reductionism or vegetarianism.

Veganism as Extremist

Vegan Outreach states in their 2009 “Why Vegan” pamphlet:


Being vegan isn’t about being perfect or pure—it’s about reducing suffering (14).
 
The 2002 version states:


Being vegan isn’t about avoiding a list of ingredients […] (14).
 
The 2008 Guide to Cruelty-Free Eating furthers that veganism can be difficult:

[…] especially if you try to change too fast or hold yourself to too high a standard.  The important thing is to do the best you can (30).
 
It’s a good thing that society doesn’t hold the same low standards for rapists.  It would be great news for molesters everywhere if they could avoid moral obligations by simply doing the best they can.

Remember:  Continuing to eat cheese while avoiding meat and eggs does much more good than scrapping the whole idea because you can’t be completely consistent (Guide to Cruelty-Free Eating 30).
 
The implication in the above quotes is that veganism is somehow difficult, unobtainable, militant, or even utopian.  Rather than defining veganism as a moral refusal to participate in violence or the absolute baseline required for taking the exploitation and use of non-human animals seriously, veganism, is instead framed as one of many opportunities for reducing suffering.  In effect, this statement refutes the moral necessity of veganism and opens the door to reductionism.  If veganism isn’t about being perfect or pure, what’s the harm in sneaking a donut with your morning coffee?

Sneaking that whey-tainted donut might be acceptable for Vegan Outreach:

For instance, it can be prohibitively expensive and time-consuming to shun every minor or hidden animal-derived ingredient.  More importantly, avoiding an ever-increasing list of these ingredients can make us appear obsessive, and thus lead others to believe that compassionate living is impossible. This defeats our purpose:  ending cruelty to animals!” (Guide to Cruelty-Free Eating 2008: 24)
 
Apparently having moral consistency and absolute abstinence against an evil is obsessive.  Does the same go for child abuse, rape, murder, or cannibalism?  Would it be acceptable to beat a child to avoid appearing obsessive?  Is it impossible to completely abstain from beating a child?  Of course it is, and there’s nothing obsessive about holding abstinence from violence and wrongdoing as the absolute baseline.

Vegetarianism and Reductionism as Progress

We can already see progress in just the past decade—public concern for farmed animals’ interests and condemnation of factory farms, as well as more vegetarians, near-vegetarians, and vegetarian products (A Meaningful Life:  Making a real Difference in Today’s World 2008: 14)
 
Is reductionism and vegetarianism really progress?  Is the underlying moral injustice being addressed if we continue to participate in non-human animal use?  Is the focus on factory farms and the ignoring of exploitation in “humane” farming progress?

Despite the organization’s name, “Vegan” Outreach, the organization is merely an animal advocacy organization which utilizes veganism as one of many tools to reduce suffering:

In order to prevent the most suffering, it’s important we each take an approach we can sustain.  After reviewing this booklet, some people may decide to go vegan immediately; others may choose to eat fewer animal products and explore more vegetarian meals.  […] …veganism is best viewed as a tool for reducing suffering (Why Vegan 200914).
 
The notion of veganism, vegetarianism, and reductionism as mere tools is perhaps most evident in their publication and distribution of the “Try Vegetarian!” pamphlet:

[…] eating vegetarian is likely the most effortless—and enjoyable!—way to have a profoundly positive impact as often as every day” (Try Vegetarian 2003).
 
As an organization that openly advocates vegetarianism, is it really appropriate to operate under the name, “Vegan Outreach?”

Vegan Outreach’s 2008 “Guide to Cruelty-Free Eating,” intended for meat eaters, vegetarians, and vegans alike, presents a results-based approach:
When you first discover the reality of modern animal agriculture, avoiding all producers from factory farms might seem too big a change.  But don’t be overwhelmed—just take small steps.  For example, you could eliminate meat from certain meals or on certain days.  As you get used to eating less meat and find alternatives you enjoy, it may become easier to eliminate meat altogether (Guide to Cruelty-Free Eating 2008: 3).
 
As a vegan outreach organization, it seems strange that veganism is not promoted as a baseline, but here, reductionism is suggested to be morally acceptable and consistent. Furthermore, this statement specifically targets factory farming.  Support of “humane” farming, then, could logically be assumed by readers to constitute a “small step.”  After all, it’s all about reducing suffering, right?

Ultimately, living with compassion means striving to maximize the good we accomplish, not following a set of rules or trying to fit a certain label.  From eating less meat to being vegan, our actions are only a means to an end:  decreasing suffering (Guide to Cruelty-Free Eating 2008: 3)
 
Can reduction of suffering ever truly be accomplished and can abolition of non-human animal use ever be reached so long as so-called vegan organizations maintain that the exploitation of non-human animals is sometimes acceptable?



For every person you persuade to become vegetarian, dozens of farmed animals will be spared from suffering each year! (A Meaningful Life 2008: 23)
 
The argument that vegetarianism somehow makes a real difference for non-human animals is an empirical fallacy.  There is no continuum whereby vegetarians necessarily progress to veganism.  Further, vegetarianism does nothing to challenge the property status of non-human animals.  Often, vegetarianism causes more suffering than it reduces in that many vegetarians simply replace non-human animal flesh with non-human animal excretions.  Milk, eggs, and other non-flesh non-human animal products involve far more suffering than that of flesh.


Veganism as the Moral Baseline

Vegan Outreach posits:

The question isn’t, “Is this vegan?” but, “What is best for preventing suffering?” (Guide to Cruelty-Free Eating 3)
 
The answer to that question is:  “GO VEGAN.”  Veganism is the only moral choice if we truly want to reduce suffering, respect the moral standing of non-human animals, and ultimately reach total abolition of non-human animal use.  There’s nothing hard about it, there’s nothing obsessive about it, and there’s nothing inconsistent about it.
More About: abolition · animal rights · welfarism

Thinking with Maynard Clark

Finishing some last minute journal scanning at the Countway Medical Library, then going home

Mobile post sent by vegetarian using Utterlireply-count Replies.

Thinking with Maynard Clark

going to sleep to be fresh for Vegan Meetup on Saturday at lunchtime: http://Vegan.Meeetup.com/23/

Mobile post sent by vegetarian using Utterlireply-count Replies.

Kimberly McCallum Files Suit Against Billy Graham Evangelistic Association

Black Woman Files Suit Against Billy Graham Evangelistic Association

Friday, September 4, 2009

(RNS) The Billy Graham Evangelistic Association has denied the claims of a black former employee who filed suit, alleging she was fired after expressing concern that the ministry was not sufficiently reaching out to African-American churches.
The racial discrimination lawsuit by Kimberly McCallum was moved Wednesday (Sept. 2) from a local court to a federal court, the Associated Press reported.
In response, the association issued a statement confirming the suit and saying it works to be inclusive.
"We cannot discuss the specifics of the pending case, except to state that we disagree with the allegations in the lawsuit," said the association, which is based in Charlotte, N.C. "The BGEA provides equal employment opportunities to people of all races. The organization continues to be inclusive of all people regardless of race, gender or nationality in all of the ministry's activities worldwide."
The suit was filed in June in a Mecklenburg County (N.C.) court, but was moved to a U.S. District Court in Charlotte.
According to the AP, the suit says McCallum complained that a list of 635 prospective congregations for a BGEA program included only three that were predominantly black.  She said she was fired a week later due to downsizing.  She seeks back pay, damages, and job reinstatement.
"Subsequent to her discharge, plaintiff learned that the global offices had not been downsized and that the only job that was eliminated there was the one occupied by the plaintiff," the suit reads.
Adelle M. Banks
Copyright 2009 Religion News Service. All rights reserved. No part of this transmission may be distributed or reproduced without written permission.

Advertisement
Add Comment » Comments
Tom
September 4, 2009 11:33 PM
But anyone who has seen him has seen the father :-)
This is a new wrinkle. Allegedly, she wasn't fired for her race per say. She was fired for 'rocking the boat' regarding outreach to people of her race. Does she have a case? Can the court determine that religious orgs that don't reach out enough to save souls of minority races are 'racist'? I'm very interested to see how this pans out. Granting her a judgment can have serious implications on church & state issues
nnmns
September 5, 2009 12:04 AM
It sounds to me, based only on this RNS article, like she has a case. If they tell her they are down-sizing but only down-size her, and that after she rocked a boat that probably hates rocking, that's some evidence. But I'm no lawyer.
cknuck
September 5, 2009 12:54 AM
I disagree Tom when you see Franklin you don't see Billy. I agree with you nnmns I think she does have a case if upon suggesting outreach to more Black churches they "downsized" her only with that cover up in mind. Here's the deal, her lawyer probably knows they will settle to avoid the negative publicity. Franklin has had to do bad decision damage control before.
Tom
September 5, 2009 9:08 AM
I agree that there's a wrongful termination case, given the minimal "downsizing". If it is, in fact, a racial discrimination suit, it would likely be necessary to prove that the "layoff" was significantly related to race and not solely because of her speaking out. But this article is very sketchy, which makes educated guessing next to impossible (and like nnmns, I'm no lawyer, but I play one in beliefnet comboxes ;-).
pagansister
September 5, 2009 8:46 PM
Adding here to the idea that she seems to have a case. I hope she wins it. The leadership will have some fancy stepping to do to get out of this one.
Read All Comments

Friday, September 04, 2009

Meatout Mondays - Every Week - Go Meatless on Monday

Meatout Mondays

Welcome to Meatout Mondays

Feeling sluggish?
Catching frequent colds?
Considering shedding a few pounds?
Want to help protect the environment and reduce global warming?
Troubled by animal suffering in factory farms and slaughterhouses?

Sounds like you're ready for Meatout Mondays!


Meatout Mondays
is a colorful weekly e-mail newsletter that delivers a delicious veg recipe, product suggestion, health news, and an inspiring story. Sign-up today and your first recipe will be sent this Friday (so you have time to get ready for Monday).

Want more? When you sign-up, you can also request your FREE Veg Starter Kit, a 32-page full-color magazine with details about the benefits of "kicking the meat habit" and helpful information on how to make the switch.
This is your opportunity to make a difference at every meal... a choice to improve your health, protect the environment, reduce global hunger, and save animals. Can't wait? Check out our past issues and 7-days worth of recipes to start.
Thank you for caring. Together, we are making better choices for a better world.
Get a free veg starter kit click here

Meatout Mondays is proudly sponsored by:

FARMIDA

Thursday, September 03, 2009

No beef with Julia’s kitchen: Her home’s new owner lacks the bone appetite


No beef with Julia’s kitchen

Her home’s new owner lacks the bone appetite

Lisa Landsverk and her daughters Rachael (left) and Teymura are among the new inhabitants of Julia Child's former house.
Lisa Landsverk and her daughters Rachael (left) and Teymura are among the new inhabitants of Julia Child's former house.(Essdras M Suarez/ Globe Staff)
By Billy Baker Globe Correspondent / August 31, 2009

CAMBRIDGE, Massachusetts, USA -
They are known for their love of cats.  At least they had that much in common.

But Lisa Landsverk, the new owner of the grand Victorian home on Irving Street in Cambridge where Julia Child, the doyenne of la cuisine bourgeoise, lived, cooked, and warbled for 43 years, has brought a bit of her own personality to the place.

Take the painting of the cow.

“Nobody says when I grow up I want to be a hamburger,’’ the painting’s caption reads.
Yes, the matriarch of Child’s former kitchen is an animal-rights activist and a vegetarian. “It’s a bit ironic,’’ Landsverk said, in an understatement.

What’s more, Landsverk is not what you would call a foodie. She likes to make simple things for dinner: pasta, burritos, reservations. But in the month since Landsverk and her husband, Harvard Law School professor Michael Klarman, moved into Child’s former home near the Harvard campus, they have found themselves the accidental caretakers of what has become a bit of a destination for food tourists.

Due to a recent movie about her life, “Julie & Julia,’’ everything Julia Child is hot. The film, based on a 2005 book by blogger Julie Powell about her attempt to cook all 524 recipes in Child’s landmark “Mastering the Art of French Cooking’’ in a single year, has catapulted Child, who died in 2004, back into the spotlight.

Child’s 48-year-old book has shot to the top of the bestseller list.

With the Julia mania has come an odd sort of attention for Landsverk, a former lawyer, and her family.

There are the lurkers outside their windows, snapping pictures of the house; the person who left a stick of butter (Child’s favorite ingredient) on their fence post; and the reporter who knocked on their door to ask what it’s like to cook on the site of hallowed culinary ground.

“The truth is that we haven’t done much cooking since we moved into the place,’’ Landsverk said.

After a bit of hesitation, she agreed to allow the reporter in to change that.

The plan was simple: Make a couple of Child’s recipes and see how it feels. Landsverk added one caveat: Everything had to be vegan because she did not want to offend her animal-rights friends. So, no butter.

Landsverk chose ratatouille for an entrée - she liked Child’s assertion that the eggplant casserole “perfumes the kitchen with the essence of Provence’’ - and, for dessert, pêches cardinal, a compote of fresh peaches with raspberry purée.

Helping her were daughters Rachael Klarman, 20, a junior at the University of Virginia, and 8-year-old Teymura.

A son, 17, was off at Japanese camp, and her oldest daughter, 22, was still in Charlottesville, Virginia, where the family lived before the move.

Rachael Klarman admits she had never heard of the famous chef before the realtor touted the Child connection to the family.

But she has become quite enthusiastic about the former occupant, recently reading “Julie & Julia’’ and Child’s memoir, “My Life in France.’’

As she walked back from a supply run to Savenor’s Market on a sweltering afternoon last week - Savenor’s was a favorite of Child’s, and she carved her signature signoff, “Bon Appétit,’’ into the sidewalk outside - Rachael Klarman said she’s been inspired to do more cooking in the kitchen, so that Child “is not rolling over in her grave.’’

Child and her husband, Paul, bought the house in 1956 for $35,000 and moved in two years later.

Paul, an artist and foreign service officer, designed the kitchen to Julia’s strict specifications, including countertops that were 2 inches higher than normal to accommodate her 6-foot-2-inch frame.

The kitchen was styled along the lines of a workshop, with the pots and pans hung from pegboards around the room, favorite knives - she had 800 - on magnetic strips between the windows, and everyday utensils in jars above the Garland range.

The pale green space changed little in Child’s time, and was familiar to many from the three cooking shows she filmed there during the 1990s.

When Child moved out in 2001, her kitchen and its contents were donated to the Smithsonian, where they are now an exhibit.

The house went through down-to-the-studs renovation, and when Lisa Landsverk and her family bought the 6,000-square-foot home in February for a reported $3.7 million, the only sign of Child’s tenure was her wine cellar, with its simple pine racks and handwritten vintage labels written by her husband.

The current kitchen is modern and white with a few stainless-steel accents. The windows and doorways are in the same place as when Child lived there, but the room has been expanded; an elevator has been removed to create a sunroom with a small dining area.

Stylewise, about the only thing the kitchen shares with Child’s is that everything has a place; in the new kitchen, that place is out of sight. Everything is so neatly concealed that Rachael said it took them a while to find the silverware drawer (it was hidden inside a larger drawer on the kitchen island).

With the ingredients ready and the cookbook open, Lisa and Rachael began making their way through the ratatouille recipe. Immediately, they realized that this was not going to be a quick meal.

“That’s very specific,’’ Lisa Landsverk said as she read Child’s directions to cut the eggplant into 3/8-inch-thick slices.

“No, there’s more,’’ Rachael Klarman said as she kept reading. “She calls for chunks with three specific dimensions. That’s impressive.’’

“And she wants us to dry each slice with a towel!’’ her mother gasped with a smile on her face. “We’re going to be here all day.’’

As they made their way through the recipes, mother and daughter began to notice a curious aspect to their conversation. They never said “the recipe wants’’ or “the book says;’’ they said “she says mind the heat’’ and “she wants us to chill the purée.’’ In “Julie & Julia,’’ Powell describes feeling that Julia was by her side like “some great big good fairy.’’
Lisa Landsverk and her daughter weren’t quite as grandiose, but agreed on one thing: Julia Child had them engaged with their dinner.

More than two hours after the cooking began, the kitchen was a mess but the food was ready. Teymura, who is chatty and a bit sassy, tried to get out of eating the ratatouille (she’d been pining for pasta), but relented when she was allowed to use chopsticks. She took one bite and announced “It’s kind of good, but not that good.’’

Rachael Klarman and her mother were more hesitant in their assessment.

After a few bites, Rachael said, almost relieved, “It tastes fine.’’ Her mother was impressed by the medley of flavors, but criticized her own technique.

“I think I overcooked the eggplant,’’ she said. “I wasn’t minding my heat like she said.’’

Correction: Because of an editing error, a Page One story yesterday about the owner of Julia Child's house gave the incorrect last name for the owner's daughter. Her name is Rachael Klarman.

http://www.boston.com/lifestyle/food/articles/2009/08/31/new_occupants_get_cooking_in_julia_childs_former_house?mode=PF

Thinking with Maynard Clark

In the LMA; heading to Countway

Mobile post sent by vegetarian using Utterlireply-count Replies.

Wednesday, September 02, 2009

PCRM Online, September 2009: Another Victory for Pigs in Canada; Celebrity Chefs Cook Vegan; Meet the Queen of Chimpanzees; and More

September 2009 Physicians Committee for Responsible Medicine  
News and Campaign Updates
pigletAnother Victory for Pigs in Canada
Life continues to improve for pigs in Canada. In July, PCRM announced an Advanced Trauma Life Support win for pigs in Toronto. Now, the University of Saskatchewan College of Medicine announced that it too will stop using live pigs in its program and exclusively use the TraumaMan System. Save Pigs in Tennessee >

dotline
Marilu Henner‘Town Hall’ and Capitol Hill Ads Call for Healthy School Lunches
Health care was debated heatedly across the United States in August. But at PCRM’s celebrity-hosted "town hall" for healthy school lunches, the only raised voices were cheering suggestions for vegetarian school lunches. And on PCRM ads in Washington, D.C., a smiling 8-year-old girl asked a polite question of the current administration: “President Obama’s daughters get healthy school lunches. Why don’t I?” Aug. 24 TV event >

dotline
chimpanzeeA Royal Visit with Negra, Queen of the Chimpanzees
It’s a long journey from Africa to Cle Elum, Wash. It was certainly a grueling trip for Negra, a 36-year-old chimpanzee who had many traumatic experiences along the way. But in Cle Elum, she found a place that—in spirit—is close to home. Last month, at the Chimpanzee Sanctuary Northwest, PCRM scientists met Negra as they continued their observation of the long-lasting psychological damage to chimpanzees previously used in laboratories. Two years solitary confinement >

dotline
Toni FioreCelebrity Chefs and New Classes Teach Plant-Based Diabetes Prevention
The new season of the TV show Top Chef just started and it’s packed with celebrity chefs. In the show’s challenges, chefs typically create high-fat, cholesterol-laden meals—like the ones that have contributed to America’s diabetes epidemic. But last month, PCRM presented its own challenge to celebrity chefs: Prepare delicious, plant-based meals that can prevent diabetes. Find a cooking class >

dotline
William Morris, M.D.Longtime Army Doctor Asks Military to End Animal Trauma Training
It doesn’t take a brain surgeon to understand that using and killing animals in trauma training is cruel and archaic. But 20 years as an Army neurosurgeon and 15 years spent treating civilian trauma provides William Morris, M.D., a solid platform when he speaks out against the military’s use of live animals in combat trauma training courses. 9,000 goats and pigs killed >

dotline
Stuart Jacobs Prize-Winning Food Service Workers Serve Veggie School Lunches
From the Golden Gate to the Peach State, school lunches are getting healthier. Cheeseburgers and chicken wings are giving way to fruits, vegetables, and low-fat vegetarian meals. As students prepare to head back to school, PCRM is honoring the winners of its 2009 Golden Carrot Awards for innovation in school food service. Who’s serving dhal-bhaat? >
dotline
credit cardMake a Choice That Benefits Animals, PCRM, and You
PCRM is excited to announce a brand new way you can show your support for the work we do! When you apply for and use the new, free PCRM Platinum® Visa Rewards Card, the bank will donate $50 and a percentage of all your future purchases on the card to PCRM. Learn More >

Tuesday, September 01, 2009

Thinking with Maynard Clark

Had a GREAT first day back at 641 Huntington Avenue in Global Health and Social Medicine at HMS/LMA.

Mobile post sent by vegetarian using Utterlireply-count Replies.

Cells don’t like to be alone

Detached Early Cancer Cells May Die from Lack of Nourishment
Antioxidants Could Rescue Starving Tumors-to-be
http://focus.hms.harvard.edu/2009/082809/antioxidants.shtml

Focus banner


Detached Early Cancer Cells May Die from Lack of Nourishment

Antioxidants Could Rescue Starving Tumors-to-be
Cells don’t like to be alone. In the early stages of tumor formation, a cell might be pushed out of its normal environment due to excessive growth. But a cell usually responds to this homeless state by dismantling its nucleus, packing up its DNA, and offering itself to be eaten by immune cells. Simply put, the homeless cell kills itself. This process, known as apoptosis, typically stops potential cancer cells before they have a chance to proliferate.
Joan Brugge
Photo by Liza Green, HMS Media Services
Joan Brugge and collaborators have identified metabolic defects with a lethal effect on cells that stray too far from their home environment. The defects might be a way for the body to stop potential tumor cells from proliferating.


Now, researchers from the lab of Joan Brugge, the Louise Foote Pfeiffer professor of cell biology and chair of that department, have discovered another mechanism that these precancerous, homeless cells use to commit suicide. By studying two different types of human breast epithelial cells, the researchers found that when separated from their natural environment, these cells lose their ability to harvest energy from their surroundings. Eventually, they starve.
“We originally thought that in order for cells to survive outside their normal environment, they would simply need to suppress apoptosis,” said Brugge, senior author on the paper, which appeared online Aug. 19 in Nature. “But our studies indicate that this activity is not sufficient to prevent the demise of homeless cells. Even if they escape apoptosis, these cells can’t transport enough glucose to sustain an energy supply.”
Surprisingly, metabolic function is restored if antioxidant activity is increased inside the cells, allowing them to use energy pathways that do not rely on glucose.
“It raises the interesting idea that antioxidants, which are typically thought to be protective because they prevent genomic damage, might be allowing these potentially dangerous cells to survive,” said first author Zachary Schafer, assistant professor at the University of Notre Dame and a former postdoc in Brugge’s lab.
“It raises the interesting idea that antioxidants, which are typically thought to be protective because they prevent genomic damage, might be allowing these potentially dangerous cells to survive.”
—Zachary Schafer
The authors caution against extrapolating too far from their data, which were based on cell culture. They also emphasize that the experiments were not designed to mimic the effect of dietary antioxidants. The researchers used two specific antioxidant compounds—chemically distinct from those found in food and supplements—only to understand how oxidants contribute to the metabolic defects.
“We think that genes with antioxidant activity play a much bigger role than antioxidant compounds administered from outside the body,” said Brugge.
Beyond Cell Suicide
The team had previously reported that when cells were endowed with a cancer-causing gene that prevents them from committing suicide, they still died when cut off from their extracellular environment. This puzzled the researchers since they had long thought that apoptosis was the only way the cells could die.
In the recent study, Schafer and colleagues took a closer look, measuring the levels of proteins and molecules associated with metabolic activity in the displaced, but apoptosis-resistant, cells. They found that the cells had become incapable of taking up glucose, their primary energy source. Under the microscope, the cells also displayed telltale signs of oxidative stress, a harmful accumulation of oxygen-derived molecules called reactive oxygen species (ROS). The result was a halt in the production of ATP, the molecular lifeblood that transports energy in the cells. The unmoored cells were literally starving to death.
“The idea that a lack of extracellular matrix can prevent cells from accessing nutrients hasn’t been shown conclusively before,” said Schafer. “Loss of glucose transport, decreased ATP production, increased oxidative stress—all those things turn out to be interrelated.”
Tumor Metabolism
To figure out what was wrong, the researchers took a direct approach: they tried to fix it. Schafer engineered the homeless cells to express high levels of a gene, HER2, known to be hyperactive in many breast tumors. He also treated the cells with antioxidants in an attempt to relieve oxidative stress and help the cells survive.
Both strategies worked. The cells with the breast cancer gene regained glucose transport, preventing ROS accumulation, and recovered their ATP levels. The antioxidant-treated cells also survived, but by using fatty acids instead of glucose as an energy source.


10A
10A Trolox
Courtesy Zachary Schafer
In these microscope images, human mammary cells (blue) grow in clusters surrounded by a membrane of extracellular matrix (red), which usually keeps them alive. Normally (left), the cells in the middle of the cluster die due to lack of contact with the extracellular matrix, leaving an empty space. In cells treated with Trolox (right), an antioxidant derived from Vitamin E, cells separated from the extracellular matrix survive, filling up the middle of the cluster.

“Our results raise the possibility that antioxidant activity might allow early-stage tumor cells to survive where they otherwise would die from these metabolic defects,” said Schafer.
The researchers are currently planning to test the effects of antioxidant genes, some of which are abnormally regulated in human tumors, and a wider range of antioxidants in animal models. They also plan on characterizing the metabolic consequences of matrix detachment in more detail.
“Ultimately,” Brugge said, “we want to understand enough about the metabolism of tumor cells so that new types of drugs can be designed to target them.”
Students may contact Joan Brugge at joan_brugge@hms.harvard.edu for more information.
Conflict Disclosure: The authors declare no conflict of interest.
Funding Sources: The National Cancer Institute and the National Institutes of Health; the authors are solely responsible for the content of this work.

top